VJHemOnc Podcast

Post-ASH AML highlights: novel approaches to frontline therapy, advances with menin inhibitors, & managing FLT3-ITD+ AML

In this podcast, we bring you exclusive updates on acute myeloid leukemia (AML) from the 66th American Society of Hematology (ASH) Annual Meeting and Exposition, which took place in San Diego, CA.

You will hear insights into novel approaches to frontline chemotherapy and BCL2 inhibition from experts Ioannis Mantzaris, MD, Montefiore Medical Center/Albert Einstein College of Medicine, New York City, NY, Tapan Kadia, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Chong Chyn Chua, MBBS, FRACP, FRCPA, The Alfred Hospital and Monash University, Melbourne, Australia. 

Eunice Wang, MD, Roswell Park Comprehensive Cancer Center, Buffalo, NY, Emma Searle, MBChB, MA, MRCP, FRCPath, PhD, The Christie NHS Foundation Trust, Manchester, UK, Joshua Zeidner, MD, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, and Amer Zeidan, MBBS, MHS, Yale University and Yale Cancer Center, New Haven, CT, will then go on to share updates on the use of menin inhibitors in relapsed/refractory (AML).

This will be followed by Mark Levis, MD, PhD, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, and Nicholas Short, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, who discuss the management of FLT3-ITD+ AML.

Post-ASH MPN highlights: key trial updates in MF, novel approaches being explored in R/R disease, & more!

This podcast episode covers key highlights in myeloproliferative neoplasms (MPNs) from the 66th American Society of Hematology (ASH) Annual Meeting and Exposition, which took place in San Diego, CA.

First, you will hear key trial updates in myelofibrosis (MF) from Andrew Kuykendall, MD, Moffitt Cancer Center, Tampa, FL, Lucia Masarova, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Francesco Passamonti, MD, University of Milan, Milan, Italy. Following this, Marina Kremyanskaya, MD, PhD, Icahn School of Medicine at Mount Sinai, New York, NY, will present initial results from the Phase I/II SANRECO trial (NCT05499013) evaluating divesiran in patients with polycythemia vera (PV). Firas El Chaer, MD, University of Virginia, Charlottesville, VA, and Claire Harrison, MD, FRCP, FRCPath, Guy’s and St Thomas’ NHS Foundation Trust, London, UK, will then give updates on trials exploring novel approaches for patients with relapsed/refractory (R/R) myelofibrosis. Finally, you will hear an update on the BOREAS trial (NCT03662126) from Prithviraj Bose, MD, The University of Texas MD Anderson Cancer Center, Houston, TX.

Post-ASH NHL highlights: novel combinations in the frontline setting and advancements with immunotherapy in the R/R setting

Today's podcast showcases key updates in non-Hodgkin lymphoma (NHL) from the 66th American Society of Hematology (ASH) Annual Meeting and Exposition, which took place in San Diego, CA.

First, you will hear from Gilles Salles, MD, PhD, Memorial Sloan Kettering Cancer Center, New York, NY, Catherine Diefenbach, MD, NYU Langone, New York, NY, and Jia Ruan, MD, PhD, Weill Cornell Medical College, New York City, NY, who discuss novel combinations being explored in the frontline setting for diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL). Sattva Neelapu, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Paolo Strati, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Nirav Niranjan Shah, MD, Medical College of Wisconsin, Milwaukee, WI, will then give updates on the use of CAR T-cells in the relapsed/refractory (R/R) setting for NHL, including follicular lymphoma (FL) and DLBCL. This will be followed by Catherine Diefenbach, MD, NYU Langone, New York, NY, and Taylor Brooks, MD, Cleveland Clinic, Cleveland, OH, who discuss the use of bispecific antibodies, and Julio Chavez, MD, Moffitt Cancer Center, Tampa, FL, who shares data on CELMoDs under investigation for the treatment of FL and DLBCL.

Post-ASH MDS highlights: managing anemia in LR-MDS and novel approaches to treating HR-MDS

This podcast is the second episode in our series spotlighting key highlights from the 66th American Society of Hematology (ASH) Annual Meeting and Exposition, which took place in San Diego, CA. This episode focuses on updates in myelodysplastic syndromes (MDS). 

You will hear insights into managing anemia in lower-risk MDS (LR-MDS) from Sophie Park, MD, CHU Grenoble Alpes, Grenoble, France, Esther Oliva, MD, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy, and Uwe Platzbecker, MD, University of Leipzig, Leipzig, Germany. They share data from the EPO-Pretar trial (NCT03223961), which is investigating early versus late onset of epoetin alfa treatment, an analysis of patient-reported outcomes in the COMMANDS trial (NCT03682536), and the effect of prior therapies on the activity of imetelstat in the IMerge trial (NCT02598661).

Andrius Žučenka, MD, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania, and Marina Konopleva, MD, PhD, Albert Einstein College of Medicine, New York City, NY, then go on to discuss novel approaches to managing higher-risk MDS (HR-MDS), including an individualized allogeneic stem cell transplantation (alloSCT) approach and novel non-transplant treatment approaches.

Post-ASH CLL highlights: BTK inhibitors & degraders, bispecific antibodies, & more!

VJHemOnc recently attended the 66th American Society of Hematology (ASH) Annual Meeting and Exposition in San Diego, CA, where we gained expert insights into cutting-edge research in hematological malignancies. This podcast series will cover highlights in a variety of disease areas. Today's episode focuses on chronic lymphocytic leukemia (CLL). 

You will hear from experts Jeff Sharman, MD, Willamette Valley Cancer Institute, Eugene, OR, Jennifer Brown, MD, PhD, Dana-Farber Cancer Institute, Boston, MA, Alexey Danilov, MD, PhD, City of Hope, Duarte, CA, Nirav Niranjan Shah, MD, Medical College of Wisconsin, Milwaukee, WI, and Chan Cheah, MBBS, FRACP, FRCPA, DMSc, Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Australia. They discuss key updates on the use of BTK inhibitors in CLL, including the BRUIN CLL-321 (NCT04666038) and AMPLIFY (NCT03836261) trials, as well as the BTK degraders NX-2127 and NX-5948. They then go on to speak about novel approaches being explored, including treatment with the bispecific antibody epcoritamab in the EPCORE-CLL1 (NCT04623541) trial, and the use of sonrotoclax in the BGB-11417-101 (NCT04277637) trial. 

Advancing treatment for BPDCN: current therapies, a deep dive into tagraxofusp, & emerging novel agents

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy characterized by involvement of the skin, bone marrow, and lymph nodes, often associated with a poor prognosis. In this podcast episode, Naveen Pemmaraju, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, provides an in-depth exploration of BPDCN. Dr Pemmaraju discusses the challenges in treating this disease and reviews current therapeutic options such as chemotherapy, tagraxofusp, and transplantation. He takes a deep dive into the CD123-targeted agent tagraxofusp, addressing patient eligibility, the role of tagraxofusp in bridging to transplantation, and real-world data on its use. Additionally, Dr Pemmaraju shares insights into ongoing clinical trials and emerging treatments for BPDCN, including novel CD123-targeted therapies, combination strategies, BCL2 inhibitors, and immunotherapeutic approaches.

Improving care for patients with SCD: pain management, ongoing projects & unmet needs

This week's podcast focuses on strategies to improve care for patients with sickle cell disease (SCD), featuring expert insights from the 19th Annual Scientific Conference on Sickle Cell and Thalassemia (ASCAT 2024), which was held in London, UK. You will hear from Natasha Archer, MD, MPH, Harvard Medical School, Boston, MA, Subarna Chakravorty, MBBS, MRCPCH, FRCPath, PhD, King’s College Hospital NHS Trust, London, UK, Christiana Dinah, BSc, MBBS, MRes, London North West Healthcare NHS Trust, Harrow, UK, Leon Tshilolo, MD, PhD, Centre Hospitalier Monkole, Kinshasa, DR Congo, and Marsha Treadwell, PhD, University Of California San Francisco, San Francisco, CA. They speak about pain management in SCD, ongoing projects including the Universal Care Plan Project and the Sickle Eye Project, and unmet needs in Sub-Saharan Africa and from a psychosocial perspective. 

Understanding BPDCN: dermatology and hematology perspectives on presentation, diagnosis, treatment, & multidisciplinary care

In this podcast, experts Marlise Luskin, MD, MSCE, Dana-Farber Cancer Institute, Boston, MA, Nicole LeBoeuf, MD, MPH, Dana-Farber Cancer Institute, Boston, MA, and Shai Shimony, MD, Dana-Farber Cancer Institute, Boston, MA, share insights into the clinical presentation, diagnosis, and treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare hematological malignancy. Dr Luskin and Dr Shimony provide insights from a hematology standpoint, while Dr LeBoeuf explores the diagnosis and pathogenesis of this rare disease through a dermatology perspective. The discussion covers pathology, patient demographics, the use of tagraxofusp and venetoclax, and the importance of collaboration within multidisciplinary teams.

Managing complications associated with WM: Bing-Neel syndrome, acquired von Willebrand disease, & more!

Today's podcast episode focuses on the management of complications associated with Waldenström's macroglobulinemia (WM), featuring expert insights from the 12th International Workshop on Waldenström's Macroglobulinemia (IWWM-12) held in Prague, Czech Republic. You will hear from Shirley D’Sa, MD, FRCP, FRCPath, University College London, London, UK, Monique Minnema, MD, PhD, University Medical Center Utrecht, Utrecht, Netherlands, and Jithma Abeykoon, MD, Mayo Clinic, Rochester, MN, who share advice on managing IgM demyelinating neuropathy, Bing-Neel syndrome, and acquired von Willebrand disease, respectively. Finally, Adam Sperling, MD, PhD, Dana Farber Cancer Institute, Boston, MA, speaks about clonal hematopoiesis in WM, giving advice on how to detect it and how it may impact treatment strategies. 

CAR-T therapies and bispecific antibodies in the treatment of high-risk multiple myeloma: updates from iwHRMM 2024

This week's podcast features discussions on the use of immunotherapy in the treatment of high-risk multiple myeloma (HRMM) from the 1st International Workshop on High-Risk Multiple Myeloma (iwHRMM), which took place Charleston, SC. You will hear from experts Ajai Chari, MD, University of California San Francisco, San Francisco, CA, and Krina Patel, MD, MSc, The University of Texas MD Anderson Cancer Center, Houston, TX, who discuss the use of CAR T-cells in the treatment of HRMM. They highlight clinical trial findings, the use of CAR-Ts in specific high-risk subgroups, and the potential for allogeneic CAR T-cell products. Additionally, Thomas Martin, MD, University of California San Francisco, San Francisco, CA, Ajai Chari, MD, University of California San Francisco, San Francisco, CA, Niels Van de Donk, MD, PhD, VU Amsterdam, Amsterdam, The Netherlands, and Saad Usmani, MD, MBA, FACP, Memorial Sloan Kettering Cancer Center, New York, NY, speak about bispecific antibodies in HRMM. They discuss strategies to optimize treatment, potential resistance mechanisms, and combination strategies.