VJHemOnc Podcast

Myeloma highlights at ASH 2022: Improving access to CAR-T therapy & future outlooks

The 64th American Society of Hematology (ASH) Annual Meeting and Exposition took place on December 10-13, 2022, in New Orleans, LA, and saw leading experts from all over the world gather to showcase the latest research in hematological malignancies.

In this podcast, Yi Lin, MD, PhD, Mayo Clinic, Rochester, MN, and Krina Patel, MD, Msc, The University of Texas MD Anderson Cancer Center, Houston, TX, share key updates in multiple myeloma presented at this year’s meeting. The experts comment on real-world experiences with access to CAR-T therapy, the importance of optimizing the sequencing of therapies, ongoing clinical trials in high-risk disease, and more.

Highlights in MDS at ASH 2022: Treating lower-risk & higher-risk disease, trial updates, & more

The 64th American Society of Hematology (ASH) Annual Meeting and Exposition took place on December 10-13, 2022, in New Orleans, LA, and saw leading experts from all over the world gather to showcase the latest research in hematological malignancies. 

In this podcast, David Sallman, MD, Moffitt Cancer Center, Tampa, FL, and Andrew Brunner, MD, Massachusetts General Hospital, Boston, MA, discuss key updates in myelodysplastic syndromes (MDS) presented at this year's meeting. Topics covered include the treatment of lower-risk and higher-risk disease, novel classification systems, clinical trial updates, and treatment options after failure to hypomethylating agents (HMAs).

iwNHL Session V: Novel therapies in NHL - the role of ADCs

The 19th International Workshop on Non-Hodgkin Lymphoma (iwNHL) 2022 took place in Barcelona, Spain, and brought together leading experts in the field as they discussed several topics. In this podcast series, you will hear the latest updates in NHL and gain an insight into the sessions that took place at this year’s meeting.

In this podcast, Laurie Sehn, MD, BC Cancer Agency, Vancouver, Canada, Carmelo Carlo Stella, MD, PhD, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Milan Italy, and David Straus, MD, Memorial Sloan Kettering Cancer Center, New York, NY, share some insights into novel therapies in non-Hodgkin lymphoma (NHL), drawing focus on the role of antibody-drug conjugates (ADCs). The experts discuss updates on the use of several ADCs, including brentuximab vedotin, loncastuximab tesirine, polatuzumab vedotin, and camidanlumab tesirine, and where these agents fit in the treatment landscape.

iwAL 2022 Session V: Mechanisms of resistance to targeted therapies in AML

The 4th International Workshop on Acute Leukemias (iwAL) 2022 took place in Nice, France, and brought together leading experts in the field as they discussed several topics. In this podcast series, you will hear the latest updates in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) and gain an insight into the sessions that took place at this year’s meeting.

In this podcast, Naval Daver, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Paresh Vyas, MRCP, FRCP, FRCPath, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK, Alexander Perl, MD, University of Pennsylvania, Philadelphia, PA, and Carsten Müller-Tidow, MD, University Hospital Heidelberg, Heidelberg, Germany, discuss mechanisms of resistance to targeted therapies in AML, and the role of epigenetics. 

The importance of genomic testing in CLL and its role in clinical decision-making

Chronic lymphocytic leukemia (CLL) remains a challenging hematological malignancy to treat, and genomic testing has become increasingly important in this disease. Several genomic tests are commonly carried out prior to initiating treatment, including testing for TP53 aberrations, IgHV mutational status, and more. 

In this podcast, you will hear from Lydia Scarfò, MD, Vita-Salute San Raffaele University & IRCCS San Raffaele Scientific Institute, Milan, Italy, Nitin Jain, MD, University of Texas MD Anderson Cancer Center, Houston, TX, Richard Rosenquist, MD, PhD, Karolinska Institute, Stockholm, Sweden, Florence Cymbalista, MD, Hôpital Avicenne, Bobigny, France, and Paolo Ghia, MD, Università Vita-Salute San Raffaele, Milan, Italy, who discuss the importance of genomic testing in CLL and how this impacts treatment decisions.

iwNHL Session IV: T-cell therapies for NHL: CAR-T therapies & third-party EBV T-cells

The 19th International Workshop on Non-Hodgkin Lymphoma (iwNHL) 2022 took place in Barcelona, Spain, and brought together leading experts in the field as they discussed several topics. In this podcast series, you will hear the latest updates in NHL and gain an insight into the sessions that took place at this year’s meeting.

In this podcast, Catherine Bollard, MBChB, MD, FRACP, FRCPA, Children's National Health System, Washington, DC, Jeremy Abramson, MD, Massachusetts General Hospital Cancer Center, Boston, MA, Barbara Savoldo, MD, PhD, UNC School of Medicine, Chapel Hill, NC, and Maksim Mamonkin, PhD, Baylor College of Medicine, Houston, TX, discuss the latest updates in T-cell therapies for the treatment of NHL, commenting on real-world data on CD19-directed CAR-Ts, and exploring the potential of other T-cell therapies including CD30, CD20, and CD5-directed CAR-Ts in T-cell lymphomas. 

Key updates in CLL: novel treatment strategies, the changing role of chemotherapy, and more

The treatment landscape of chronic lymphocytic leukemia (CLL) has transformed over the years with the increased use of Bruton's tyrosine kinase (BTK) inhibitors, which have demonstrated promising results in several clinical trials. 

In this podcast, leading experts Nitin Jain, MD, University of Texas MD Anderson Cancer Center, Houston, TX, and Catherine Coombs, MD, UC Irvine Health, Orange, CA, discuss key updates in CLL, including the changing role of chemotherapy in the era of novel agents, the promise of next-generation BTK inhibitors, and more. This discussion took place at the 10th Annual Meeting of the Society of Hematologic Oncology (SOHO), which was held in Houston, TX, from September 28-October 1.

iwAL 2022 Session IV: The evolving treatment landscape in ALL and the growing role of immunotherapies

The 4th International Workshop on Acute Leukemias (iwAL) 2022 took place in Nice, France, and brought together leading experts in the field as they discussed several topics. In this podcast series, you will hear the latest updates in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) and gain an insight into the sessions that took place at this year’s meeting.

In this podcast, you will hear from Bijal Shah, MD, H. Lee Moffitt Cancer Center, Tampa, FL, Sabina Chiaretti, MD, PhD, Sapienza University of Rome, Rome, Italy, Elias Jabbour, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Nicolas Boissel, MD, PhD, Saint-Louis Hospital, Paris, France, who discuss the evolving treatment landscape in ALL, debating the role of immunotherapies, including antibody-drug conjugates (ADCs) and CAR-T cells.

iwNHL Session III: Exploring the optimal management of R/R follicular lymphoma in an expanding treatment landscape

The 19th International Workshop on Non-Hodgkin Lymphoma (iwNHL) 2022 took place in Barcelona, Spain, and brought together leading experts in the field as they discussed several topics. In this podcast series, you will hear the latest updates in NHL and gain an insight into the sessions that took place at this year’s meeting.

This podcast episode focuses on the optimal management of relapsed/refractory (R/R) follicular lymphoma (FL), where you will hear from Laura Pasqualucci, MD, Columbia University Irving Medical Center, New York, NY, Jessica Okosun, MA, MB BChir, MRCP, FRCPath, PhD, Barts Cancer Institute, Queen Mary University of London, London, UK, and David Qualls, MD, Memorial Sloan Kettering Cancer Center, New York, NY. The experts debate on how to best treat, combine, and sequence therapies in R/R FL, and further comment on the role of epigenetic alterations in this disease. 

iwAL 2022 Session III: Novel targets, combinations and treatment strategies in AML

The 4th International Workshop on Acute Leukemias (iwAL) 2022 took place in Nice, France, and brought together leading experts in the field as they discussed several topics. In this podcast series, you will hear the latest updates in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) and gain an insight into the sessions that took place at this year’s meeting.

In this podcast, Richard Stone, MD, Dana-Farber Cancer Institute, Boston, MA, David Sallman, MD, H. Lee Moffitt Cancer Center, Tampa, FL, and Thomas Cluzeau, MD, PhD, Central University Hospital of Nice, Nice, France, discuss novel targets and combinations in AML, treatment approaches for patients with TP53-mutated disease, and more.