VJHemOnc Podcast

The MPN Sessions: pathobiology, therapeutic strategies & clinical trials

Myeloproliferative neoplasms (MPNs) are a group of hematopoietic stem cell diseases characterized by the excessive production of one or more myeloid lineage with largely intact cellular differentiation. Recent advances in the field, such as the detection of new driver mutations and a better understanding of the molecular pathogenesis of MPNs, have revolutionized the diagnosis, classification and treatment of these hematological malignancies.

The First Texas MPN Workshop brought together medical experts in the field of MPNs to discuss the latest research and therapy options in development for MPNs. In this podcast, Ruben Mesa, MD, FACP, UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX, Claire Harrison, MD, FRCP, FRCPath, Guy's and St Thomas' NHS Foundation Trust, London, UK and Naveen Pemmaraju, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discuss the evolving management of MPNs, including learnings following COVID-19, mutations and molecular definitions of disease, interferon-based therapies, clinical trial updates and takeaways from the 2020 Texas MPN Workshop.

Latest AML therapies: novel preparations and first in class agents

Acute myeloid leukemia (AML) is the most common type of acute leukemia among adults with almost 20,000 new cases reported in the US in 2020. With the identification of recurrent mutations and the development of novel agents, stratification has allowed for improvements in patient outcomes. In this podcast, Thomas Cluzeau, MD, PhD, of the Central University Hospital of Nice, Nice, France, Naval Daver, MD, of the University of Texas MD Anderson Cancer Center, Houston, TX, and Andrew Wei, MBBS, PhD, of Alfred Hospital and Monash University, Melbourne, Australia, discuss key updates in the AML field presented at EHA 2020.

Advances in the lymphoma space: targeted therapies, PET-guided omission of RT and CAR T-cells

Lymphoma encompasses a wide selection of cancers that progress in the lymphatic system. Broadly, two types of lymphoma exist, non-Hodgkin lymphoma which is the 7th most common cancer type in the US and UK, and conversely, Hodgkin lymphoma which constitutes 0.5-1% of all cancers reported in the US and UK. Treatment strategies depend on the type of lymphoma, as well as location and staging. Recent treatment developments include novel chemotherapy agents and immunotherapies including CAR T-cells and antibody-drug conjugates. In this podcast, Wendy Osborne, of Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK, Peter Borchmann, from the University Hospital Cologne, Cologne, Germany, and Caron Jacobson, of the Dana-Farber Cancer Institute, Boston, MA, discuss updates in the lymphoma field presented at this year’s
virtual EHA meeting.

The Myeloma Sessions: Evolving management of myeloma & COVID-19

Patients with cancer frequently exhibit poorer post-COVID-19 infection outcomes, therefore the management of patients with hematological malignancies remains of high importance. Several strategies have been employed to reduce the risk of infection, whilst still providing appropriate therapies for high-risk patients.

In this podcast, Paul Richardson, of the Dana-Farber Cancer Institute, Boston, MA, chairs a thoughtful discussion with María-Victoria Mateos of the University Hospital of Salamanca, Salamanca, Spain, Evangelos Terpos of the University of Athens, Athens, Greece, and Ajai Chari of Mount Sinai, New York, NY, on the treatment of multiple myeloma in the face of the COVID-19 pandemic. The speakers discuss evolving strategies to reduce risk of COVID-19 infection in myeloma patients, perspectives from Spain, New York, and Greece, recommendations from the International Myeloma Society (IMS), as well as the key updates following the virtual ASCO and EHA meetings.

CLL: MRD and first-in-class agents

Chronic lymphocytic leukemia (CLL) is a disorder characterized by morphologically mature but immunologically less mature lymphocytes, which accumulate in the bone marrow, lymphatic tissue and blood. CLL generally affects the older population and is incurable, however, several novel treatment approaches have developed to improve outcomes of patients with CLL and there is an increasing use of minimal residual disease (MRD) in disease monitoring. In this podcast, Lydia Scarfò, of Vita-Salute San Raffaele University & IRCCS San Raffaele Scientific Institute, Milan, Italy, Othman Al-Sawaf of the University Hospital of Cologne, Cologne, Germany, and Tanya Siddiqi, from City of Hope, Duarte, CA discuss key developments in the treatment of CLL presented at this years EHA meeting.

MPNs highlights at EHA 2020: clinical trials, novel therapies & pitfalls

It is an exciting time in terms of therapeutic progress for myeloproliferative neoplasms (MPN). In recent years, there have been significant advances in the understanding of MPNs, including underlying genetic changes that drive the development of MPNs. This has led to research focusing on targeted therapy and increased the availability of new treatment options.

In this podcast, Srdan Verstovsek, MD, PhD, of the University of Texas MD Anderson Cancer Center, Houston, TX, Claire Harrison, MD, DM, FRCP, FRCPath, of Guy’s and St Thomas’ NHS Foundation Trust, London, UK, and Abdulraheem Yacoub, MD, of the University of Kansas Medical Center, Kansas City, MO, discuss key updates in the treatment and management of MPNs from this year’s European Hematology Association (EHA) 2020 congress.

The CLL Sessions: frontline therapy, BTK inhibitors, MRD negativity & novel therapies

A remarkable increase in the understanding of the pathogenesis of chronic lymphocytic leukemia (CLL) has led to the development of innovative therapies which has generated rapid progress in the management of CLL.

In this podcast, John Gribben of Barts Cancer Institute, London, UK, chairs an insightful discussion with Barbara Eichhorst of the University of Cologne, Cologne, Germany, Susan O’Brien of the University of California, Irvine, CA, and Matthew Davids of Dana-Farber Cancer Institute, Boston, MA, on the latest CLL updates from the recent Virtual ASCO and EHA 2020 Meetings. The speakers discuss frontline therapy for CLL, BTK inhibitors, novel combination therapies and the importance of measurable residual disease (MRD) assessment. Treatment sequencing and novel therapies, in particular CAR T-cell approaches were also discussed.

The HemOnc & COVID-19 Sessions: treating hematological malignancies, reducing nosocomial COVID-19 infections, clinical trial participation and resourc...

The ongoing COVID-19 pandemic caused by SARS-CoV-2 is an international public health issue and patients with cancer consistently demonstrate poorer...

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The AML Sessions: emerging immunotherapies, venetoclax-based regimens and targeted therapies in AML

The acute myeloid leukemia (AML) field has witnessed rapid evolution of late, with exciting developments in strategies for the treatment...

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Key updates in ALL at EHA 2020

Acute lymphoblastic leukemia (ALL) is a malignant disorder of lymphoid progenitor cells affecting both adults and children. With a greater...

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