VJHemOnc Podcast

Classifying frailty and approaching elderly patients with lymphoma

While the treatment landscape of both Hodgkin and non-Hodgkin lymphoma (HL; NHL) has improved in recent years, there are several challenges associated with treating elderly patients in these disease settings. The presence of comorbidities, as well as the risk of treatment-related toxicities, makes the treatment of elderly patients an important area of research.

In this podcast, Pallawi Torka, MD, Memorial Sloan Kettering Cancer Center, New York City, NY, and Jonathan Friedberg, MD, MMSc, University of Rochester, Rochester, NY, discuss challenges with classifying frailty in elderly patients with diffuse large B-cell lymphoma (DLBCL) and HL, as well as treatment options available to these patients.

Updates on the diagnosis, risk stratification and treatment of lower-risk MDS

The treatment and management of lower-risk myelodysplastic syndromes (LR-MDS) has remained a challenge in the field, and several studies are being conducted with the goal of improving the understanding of this disease. Furthermore, there have been recent updates to classification systems for MDS, including the Molecular International Prognostic Scoring System (IPSS-M). 

In this podcast, you will hear from Sanam Loghavi, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Rami Komrokji, MD, Moffitt Cancer Center, Tampa, FL, who discuss recent updates in the diagnosis, risk stratification and treatment of LR-MDS. This discussion was filmed at the Eleventh Annual Meeting of the Society of Hematologic Oncology (SOHO 2023) held in Houston, TX.

iwAL 2023 Session III: The relevance of TP53 mutation in AML

The 5th International Workshop on Acute Leukemias (iwAL 2023) took place in San Diego, CA, and brought together leading experts in acute myeloid leukemia (AML) as they discussed the latest updates in the field. In this podcast series, you will hear the latest advances in AML and gain an insight into the sessions that took place at this year’s meeting.

In this podcast, Andrew Wei, MBBS, PhD, Peter MacCallum Cancer Centre and the Royal Melbourne Hospital, Melbourne, Australia, and Sanam Loghavi, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discuss the relevance of TP53 mutation in AML, highlighting prognostic approaches and therapeutic strategies for this patient population. 

iwAL 2023 Session II: Novel treatments in AML: FLT3 inhibitors, combinations, and more

The 5th International Workshop on Acute Leukemias (iwAL 2023) took place in San Diego, CA, and brought together leading experts in acute myeloid leukemia (AML) as they discussed the latest updates in the field. In this podcast series, you will hear the latest advances in AML and gain an insight into the sessions that took place at this year’s meeting.

In this podcast, Naval Daver, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Gail Roboz, MD, Weill Cornell Medicine, New York City, NY, Harry Erba, MD, PhD, Duke University, Durham, NC, and Jessica Altman, MD, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, discuss new treatments in AML, drawing focus on FLT3 inhibitors, novel combinations, and treating patients with relapsed disease.

iwAL 2023 Session I: Clonal hematopoiesis in AML, early detection and potential therapeutics

The 5th International Workshop on Acute Leukemias (iwAL 2023) took place in San Diego, CA, and brought together leading experts in acute myeloid leukemia (AML) as they discussed the latest updates in the field. In this podcast series, you will hear the latest advances in AML and gain an insight into the sessions that took place at this year’s meeting.

In this podcast, Ravi Majeti, MD, PhD, Stanford University, Stanford, CA, Courtney DiNardo, MD, MSCE, The University of Texas MD Anderson Cancer Center, Houston, TX, Uma Borate, MBBS, The Ohio State University Comprehensive Cancer Center, Columbus, OH, and Koichi Takahashi, MD, PhD, The University of Texas MD Anderson Cancer Center, Houston, TX, discuss clonal hematopoiesis (CH) in AML, early detection and intervention, and potential therapeutic strategies.

Applications of MRD in multiple myeloma: using MRD to guide treatment decisions

Measurable residual disease (MRD) has become a key biomarker in the field of multiple myeloma (MM), and the sensitivity of MRD testing has increased in recent years. MRD can indicate the depth of response to treatment as well as patient outcomes, leading to suggestions of using MRD status to guide the treatment of patients with myeloma. 

In this podcast, you will hear from Meral Beksac, MD, Ankara University, Ankara, Turkey, Luciano Costa, MD, PhD, UAB School of Medicine, Birmingham, AL, and Bruno Paiva, PhD, University of Navarra, Pamplona, Spain, who discuss the exciting potential applications of MRD in multiple myeloma and share insights from recent clinical trials.

Exploring and comparing the curative potential of CAR-T therapy & bispecific antibodies in R/R DLBCL

The treatment and management of relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) remains a major unmet need, and in recent years, the introduction of immunotherapies including CAR-T cells and bispecific antibodies has provided hope for several patients.

While both CAR-T cells and bispecific antibodies have their benefits, there are several factors to consider when evaluating their curative potential in R/R DLBCL. In this podcast, you will hear from Manali Kamdar, MD, University of Colorado, Aurora, CO, Anna Sureda, MD, PhD, Catalan Institute of Oncology, Duran I Reynals Hospital, Barcelona, Spain, and Gloria Iacoboni, MD, Vall d’Hebron Institute of Oncology, Barcelona, Spain, who share some insights into the value of CAR-T cells and bispecifics in R/R DLBCL, the benefits and drawbacks of these agents, and further comment on their efficacy and curative potential.

Pre-MDS states: improving prognosis, novel therapeutic approaches, and challenges with distinguishing these conditions

Myelodysplastic syndromes (MDS) represent a heterogeneic group of disorders which remain a challenge to diagnose and treat. In recent years, there has been an increased interest in understanding various pre-MDS states, including idiopathic cytopenia of unknown significance (ICUS), clonal hematopoiesis of indeterminate potential (CHIP), and clonal cytopenia of unknown significance (CCUS). The identification and classification of these pre-MDS states remains a challenge in the field, and it is important to continue developing distinct criteria to distinguish between these states and overt disease.

In this podcast, you will hear from Moshe Mittelman, MD, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, and Klaus Metzeler, MD, University of Leipzig Medical Center, Leipzig, Germany, who discuss approaches used to identify patients with pre-MDS states, the importance of early intervention, and challenges with distinguishing these conditions. The experts also highlight strategies that may be used to improve diagnosis, and further discuss treatment approaches being explored for these individuals.

Accelerated-phase MPNs: mutational landscape, challenges, and novel treatment strategies being explored

Patients with BCR-ABL negative myeloproliferative neoplasms (MPNs) are at risk of progressing to accelerated-phase or blast-phase disease (MPN-AP/BP). Several mutations, including ASXL1, EZH2, and TP53, are involved in progression to MPN-AP/BP, and there are a number of challenges with treating patients who progress to this stage. 

In this podcast, Anand Patel, MD, University of Chicago, Chicago, IL, Andrew Kuykendall, MD, Moffitt Cancer Center, Tampa, FL, and Jan Philipp Bewersdorf, MD, Memorial Sloan Kettering Cancer Center, New York City, NY, discuss the mutational landscape of MPN-AP, and further highlight challenges with treating patients. The experts also comment on novel therapeutic strategies being explored in this space.

Determining the optimal sequencing of bispecifics and CAR-T cells in multiple myeloma

Bispecific antibodies and CAR-T cells have transformed the myeloma treatment landscape in recent years, providing hope for patients with relapsed/refractory (R/R) disease. While both of these therapies offer benefits to patients, there are challenges to address regarding the optimal sequencing of these agents.

In this podcast, experts Salomon Manier, MD, PhD, Lille University Hospital, Lille, France, Surbhi Sidana, MD, Stanford University, Stanford, CA, and Hermann Einsele, MD, FRCP, University of Würzburg, Würzburg, Germany, share some interesting insights into the optimal sequencing of bispecific antibodies and CAR-T cells in myeloma, highlighting data from recent clinical trials.