VJHemOnc Podcast

Myeloma highlights at EHA 2023: CARTITUDE-4 & CARTITUDE-1 updates & the use of MRD in clinical practice

In recent years, CAR-T cell therapy has transformed the myeloma treatment landscape and has provided a valuable option to patients with relapsed/refractory (R/R) disease. Several clinical trials are evaluating the efficacy of CAR-T cells and are further exploring the possibility of bringing these agents into earlier lines of therapy. At the 2023 EHA meeting, leading experts from around the globe came together to discuss the latest updates in all areas of hematological oncology.

In this podcast, you will hear from Jesús San Miguel, MD, University of Navarra, Pamplona, Spain, and Enrique Ocio, MD, PhD, Marqués de Valdecilla University Hospital, Santander, Spain, who share some updates from the CARTITUDE-4 and CARTITUDE-1 trials (NCT04181827; NCT03548207), and further comment on current and emerging uses of measurable residual disease (MRD) in clinical practice.

Lymphoma highlights at EHA 2023: sequencing bispecifics & CAR-T cells, bridging therapy & toxicity management

The treatment landscape of large B-cell lymphoma (LBCL) has transformed in recent years, with novel immunotherapies including bispecific antibodies and CAR-T cells demonstrating promising results. At the 2023 EHA meeting, leading experts from around the globe came together to discuss the latest updates in all areas of hematological oncology. 

In this podcast, you will hear from Gloria Iacoboni, MD, Vall d’Hebron University Hospital, Barcelona, Spain, and Paolo Strati, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, who share some insights into recent advances in CAR-T therapy and bispecific antibodies in the treatment of LBCL. Topics covered include the sequencing of these agents, bridging therapies, and managing toxicities and cytopenias after CAR-T therapy. 

iwCAR-T Session IV: CAR-T therapy in CLL: challenges, combination approaches and ongoing trials

The 5th International Workshop on CAR-T (iwCAR-T) took place in Scottsdale, AZ, on 14 – 16 April, 2023, and brought together world-leading experts in CAR-T therapy as they discussed the latest in the field. In this podcast series, you will gain an insight into the sessions that took place at this year’s meeting, which covered the latest updates in CAR-T therapy in chronic lymphocytic leukemia (CLL), lymphoma, acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and more.

In this podcast, you will hear from John Gribben, MD, DSc, FRCP, FRCPath, FMed Sci, Barts Cancer Institute, London, UK, Joseph Melenhorst, PhD, Cleveland Clinic, Cleveland, OH, and Tanya Siddiqi, MD, City of Hope, Duarte, CA, who discuss challenges with implementing CAR-T therapy in CLL, ongoing clinical trials, and research exploring combination approaches with CAR-T cells and Bruton's tyrosine kinase (BTK) inhibitors.

MDS 2023 highlights: managing anemia in lower-risk MDS & overcoming treatment failure in higher-risk disease

Therapeutic agents for patients with myelodysplastic syndromes (MDS) are currently under active investigation in clinical trials. The management of cytopenias, including anemia, is an important component in the treatment of lower-risk MDS (LR-MDS), and many agents are being evaluated to better manage these. In the context of higher-risk MDS (HR-MDS), many patients may fail to respond to novel agents and the reasons for these failures are a key topic of discussion in the field.

In this podcast, you will hear from Amer Zeidan, MBBS, Yale University and Yale Cancer Center, New Haven, CT, and Valeria Santini, MD, University of Florence, Florence, Italy, as they discuss the management of anemia in LR-MDS and strategies to overcome treatment failure in HR-MDS. This discussion was filmed at the 17^th International Congress on Myelodysplastic Syndromes (MDS) 2023, held in Marseille, France.

iwCAR-T Session III: CAR-T therapy in AML: ongoing challenges and strategies to improve patient outcomes

The 5th International Workshop on CAR-T (iwCAR-T) took place in Scottsdale, AZ, on 14 – 16 April, 2023, and brought together world-leading experts in CAR-T therapy as they discussed the latest in the field. In this podcast series, you will gain an insight into the sessions that took place at this year’s meeting, which covered the latest updates in CAR-T therapy in chronic lymphocytic leukemia (CLL), lymphoma, acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and more.

In this podcast, you will hear from David Sallman, MD, Moffitt Cancer Center, Tampa, FL, Marion Subklewe, MD, Ludwig-Maximilians University, Munich, Germany, and Roman Shapiro, MD, Dana-Farber Cancer Institute, Boston, MA, who discuss major challenges with CAR-T therapy in AML, strategies to improve outcomes for patients, and more. 

iwCAR-T Session II: CAR-T therapy in ALL: ongoing challenges and future outlooks

The 5th International Workshop on CAR-T (iwCAR-T) took place in Scottsdale, AZ, on 14 – 16 April, 2023, and brought together world-leading experts in CAR-T therapy as they discussed the latest in the field. In this podcast series, you will gain an insight into the sessions that took place at this year’s meeting, which covered the latest updates in CAR-T therapy in chronic lymphocytic leukemia (CLL), lymphoma, acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and more.

In this podcast, you will hear from leading experts Bijal Shah, MD, Moffitt Cancer Center, Tampa, FL, Rebecca Gardner, MD, Seattle Children's Hospital, Seattle, WA, Claire Roddie, MD, PhD, University College London Hospitals NHS Foundation Trust, London, UK, and Nirav Shah, MD, Medical College of Wisconsin, Milwaukee, WI, who discuss the latest updates with CAR-T therapy in ALL. The experts share some insights into challenges with implementing CAR-T therapy in this disease, and further explain strategies to improve the efficacy of these agents. 

iwCAR-T Session I: CAR-T therapy in lymphoma and the role of bispecific antibodies

The 5th International Workshop on CAR-T (iwCAR-T) took place in Scottsdale, AZ, on 14 – 16 April, 2023, and brought together world-leading experts in CAR-T therapy as they discussed the latest in the field. In this podcast series, you will gain an insight into the sessions that took place at this year’s meeting, which covered the latest updates in CAR-T therapy in chronic lymphocytic leukemia (CLL), lymphoma, acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and more.

In this podcast, you will hear from Loretta Nastoupil, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Tycel Phillips, MD, City of Hope, Duarte, CA, and Mazyar Shadman, MD, Fred Hutchinson Cancer Research Center, Seattle, WA, who share some updates on CAR-T therapy in lymphoma, and further discuss where bispecific antibodies may fit in the treatment landscape.

iwMyeloma Session III: reaching a cure for multiple myeloma and concepts that need to be addressed

The 16th International Workshop on Multiple Myeloma (iwMyeloma) 2023 took place in Madrid, Spain, and brought together leading clinicians and researchers who discussed several topics. In this podcast series, you will hear the latest updates in the treatment of multiple myeloma and gain an insight into the sessions that took place at this year’s meeting.

In this podcast, Gareth Morgan, MD, PhD, FRCP, FRCPath, NYU Langone, New York City, NY, Pieter Sonneveld, MD, PhD, Erasmus University, Rotterdam, The Netherlands, and Sagar Lonial, MD, Winship Cancer Institute of Emory University, Atlanta, GA, discuss the possibility of reaching a cure in multiple myeloma, and further highlight concepts that need to be addressed to deliver this to patients.

The current role of stem cell transplantation in MPNs & how this may change with novel agents

Myeloproliferative neoplasms (MPNs) represent a heterogeneous group of diseases which remain a challenge to treat. While there have been several advances in the MPN treatment landscape, allogeneic stem cell transplantation (alloSCT) remains the only curative option for patients. There are several important factors to consider when selecting patients for transplant, and the introduction of novel targeted therapies may further impact the role of alloSCT in MPNs.

In this podcast, you will hear from Ruben Mesa, Levine Cancer Institute, Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, Jeanne Palmer, MD, Mayo Clinic, Phoenix, AZ, Claire Harrison, MD, FRCP, FRCPath, Guy’s & St Thomas’ NHS Foundation Trust, London, UK, and Haris Ali, MD, City of Hope, Duarte, CA, who discuss the current role of alloSCT in MPNs and how this may change with novel agents.

iwMyeloma Session II: the tumor microenvironment and mechanisms of resistance to targeted therapies

The 16th International Workshop on Multiple Myeloma (iwMyeloma) 2023 took place in Madrid, Spain, and brought together leading clinicians and researchers who discussed several topics. In this podcast series, you will hear the latest updates in the treatment of multiple myeloma and gain an insight into the sessions that took place at this year’s meeting.

In this podcast, Irene Ghobrial, MD, Dana-Farber Cancer Institute, Boston, MA, Paola Neri, MD, PhD, University of Calgary, Calgary, AB, Canada, Lawrence Boise, PhD, Winship Cancer Institute of Emory University, Atlanta, GA, and Charlotte Pawlyn, BA, MBBChir, MRCP, PhD, FRCPath, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK, discuss the tumor microenvironment, the immune microenvironment, and mechanisms of resistance to agents including IMiDs, bispecifics and CAR-T cells.