VJHemOnc Podcast

iwCAR-T Session II: CAR-T therapy in ALL: ongoing challenges and future outlooks

The 5th International Workshop on CAR-T (iwCAR-T) took place in Scottsdale, AZ, on 14 – 16 April, 2023, and brought together world-leading experts in CAR-T therapy as they discussed the latest in the field. In this podcast series, you will gain an insight into the sessions that took place at this year’s meeting, which covered the latest updates in CAR-T therapy in chronic lymphocytic leukemia (CLL), lymphoma, acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and more.

In this podcast, you will hear from leading experts Bijal Shah, MD, Moffitt Cancer Center, Tampa, FL, Rebecca Gardner, MD, Seattle Children's Hospital, Seattle, WA, Claire Roddie, MD, PhD, University College London Hospitals NHS Foundation Trust, London, UK, and Nirav Shah, MD, Medical College of Wisconsin, Milwaukee, WI, who discuss the latest updates with CAR-T therapy in ALL. The experts share some insights into challenges with implementing CAR-T therapy in this disease, and further explain strategies to improve the efficacy of these agents. 

iwCAR-T Session I: CAR-T therapy in lymphoma and the role of bispecific antibodies

The 5th International Workshop on CAR-T (iwCAR-T) took place in Scottsdale, AZ, on 14 – 16 April, 2023, and brought together world-leading experts in CAR-T therapy as they discussed the latest in the field. In this podcast series, you will gain an insight into the sessions that took place at this year’s meeting, which covered the latest updates in CAR-T therapy in chronic lymphocytic leukemia (CLL), lymphoma, acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and more.

In this podcast, you will hear from Loretta Nastoupil, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Tycel Phillips, MD, City of Hope, Duarte, CA, and Mazyar Shadman, MD, Fred Hutchinson Cancer Research Center, Seattle, WA, who share some updates on CAR-T therapy in lymphoma, and further discuss where bispecific antibodies may fit in the treatment landscape.

iwMyeloma Session III: reaching a cure for multiple myeloma and concepts that need to be addressed

The 16th International Workshop on Multiple Myeloma (iwMyeloma) 2023 took place in Madrid, Spain, and brought together leading clinicians and researchers who discussed several topics. In this podcast series, you will hear the latest updates in the treatment of multiple myeloma and gain an insight into the sessions that took place at this year’s meeting.

In this podcast, Gareth Morgan, MD, PhD, FRCP, FRCPath, NYU Langone, New York City, NY, Pieter Sonneveld, MD, PhD, Erasmus University, Rotterdam, The Netherlands, and Sagar Lonial, MD, Winship Cancer Institute of Emory University, Atlanta, GA, discuss the possibility of reaching a cure in multiple myeloma, and further highlight concepts that need to be addressed to deliver this to patients.

The current role of stem cell transplantation in MPNs & how this may change with novel agents

Myeloproliferative neoplasms (MPNs) represent a heterogeneous group of diseases which remain a challenge to treat. While there have been several advances in the MPN treatment landscape, allogeneic stem cell transplantation (alloSCT) remains the only curative option for patients. There are several important factors to consider when selecting patients for transplant, and the introduction of novel targeted therapies may further impact the role of alloSCT in MPNs.

In this podcast, you will hear from Ruben Mesa, Levine Cancer Institute, Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, Jeanne Palmer, MD, Mayo Clinic, Phoenix, AZ, Claire Harrison, MD, FRCP, FRCPath, Guy’s & St Thomas’ NHS Foundation Trust, London, UK, and Haris Ali, MD, City of Hope, Duarte, CA, who discuss the current role of alloSCT in MPNs and how this may change with novel agents.

iwMyeloma Session II: the tumor microenvironment and mechanisms of resistance to targeted therapies

The 16th International Workshop on Multiple Myeloma (iwMyeloma) 2023 took place in Madrid, Spain, and brought together leading clinicians and researchers who discussed several topics. In this podcast series, you will hear the latest updates in the treatment of multiple myeloma and gain an insight into the sessions that took place at this year’s meeting.

In this podcast, Irene Ghobrial, MD, Dana-Farber Cancer Institute, Boston, MA, Paola Neri, MD, PhD, University of Calgary, Calgary, AB, Canada, Lawrence Boise, PhD, Winship Cancer Institute of Emory University, Atlanta, GA, and Charlotte Pawlyn, BA, MBBChir, MRCP, PhD, FRCPath, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK, discuss the tumor microenvironment, the immune microenvironment, and mechanisms of resistance to agents including IMiDs, bispecifics and CAR-T cells.

iwMyeloma Session I: genomics of high-risk and smoldering multiple myeloma

The 16th International Workshop on Multiple Myeloma (iwMyeloma) 2023 took place in Madrid, Spain, and brought together leading clinicians and researchers who discussed several topics. In this podcast series, you will hear the latest updates in the treatment of multiple myeloma and gain an insight into the sessions that took place at this year's meeting. 

In this podcast, Leif Bergsagel, MD, Mayo Clinic, Phoenix, AZ, Francesco Maura, MD, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, Jill Corre, PharmD, PhD, The Cancer University Institute of Toulouse Oncopole (IUCT), Toulouse, France, and Niels Weinhold, PhD, University Hospital Heidelberg, Heidelberg, Germany, discuss the genomics of high-risk multiple myeloma and smoldering myeloma. Topics covered include the importance of next-generation sequencing (NGS), the role of del(17p) and TP53 mutations, and more.

The important role of transplantation in AML: improving outcomes for patients & the value of pre-transplant MRD

Allogeneic stem cell transplantation (alloSCT) remains a valuable treatment option for fit patients with acute myeloid leukemia (AML), and the importance of measurable residual disease (MRD) monitoring in this malignancy is well established. Several clinicians and researchers are conducting trials to further evaluate how to improve outcomes for patients undergoing alloSCT.

In this podcast, you will hear from Charles Craddock, CBE, FRCP(UK), FRCPath, DPhil, University of Birmingham, Birmingham, UK, and Christopher Hourigan, MD, DPhil, National Institutes of Health, Bethesda, MD, who discuss the important role of transplantation in AML, the value of pre-transplant MRD, and more. This discussion was filmed at the 18th International Symposium on Acute Leukemias (ISALXVIII), held in Munich, Germany. 

Insights into the changing role of chemotherapy in lymphoma

Although several novel agents have been implemented in the treatment of Hodgkin and non-Hodgkin lymphoma (HL; NHL), chemotherapy remains the backbone of treatment, both in the frontline and relapsed settings.

In this podcast, you will hear from Anna Sureda, MD, PhD, Catalan Institute of Oncology, Duran I Reynals Hospital, Barcelona, Spain, who shares some insights into the current role of chemotherapy in HL and various subtypes of NHL, and further explains how novel therapies, including CAR-T cells and antibodies, are changing the treatment landscape of these diseases.

Comparing the ICC and WHO classifications for MDS and their impact on clinical practice

Recently, the International Consensus Classification (ICC) and World Health Organization (WHO) classification systems for myelodysplastic syndromes (MDS) were updated and published. Although these two systems are similar, there are key differences which must be taken into consideration by clinicians when diagnosing patients.

In this podcast, experts Amer Zeidan, MBBS, Yale University and Yale Cancer Center, New Haven, CT, Sanam Loghavi, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Rami Komrokji, MD, and Somedeb Ball, MD, Moffitt Cancer Center, Tampa, FL, discuss the latest updates in the classification of MDS and share some insights into how these may impact clinical practice.

Managing and treating toxicities associated with CAR-T therapy: CRS, ICANS & infections

CAR-T cell therapy represents a major breakthrough in the treatment of hematological malignancies, including multiple myeloma, non-Hodgkin lymphoma (NHL), and acute lymphoblastic leukemia (ALL). However, there are several toxicities associated with these agents, including cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and infections.

In this podcast, you will hear from experts Eleni Gavriilaki, MD, PhD, G. Papanikolaou Hospital, Thessaloniki, Greece, Kevin McNerney, MD, MSc, Johns Hopkins All Children’s Hospital, St. Petersburg, FL, and Andriyana Bankova, MD, University Hospital Zurich, Zurich, Switzerland, who share some insights into the treatment and management of these common toxicities.